Protecting women from men who are confused about their sexuality IS reasonable. Fortunately, we don't need to worry about trans women because they aren't confused. That's how Maher should have replied. Unfortunately, that show isn't necessarily the greatest platform for calm discussion.
Milo strikes me as a guy who wants attention and will take it any way he can get it, good or bad. Kind of like someone with Borderline Personality Disorder. I haven't read a bunch of his stuff, but from what I have read, he doesn't come across as particularly groundbreaking or insightful... no, he just wants attention.
describes it in better detail here: http://www.salon.com/2017/02/18/bill-mah…