At first, Side Effects presents itself as a straightforward drama in which a young woman (Rooney Mara) awaits the release of her insider-trading husband (Channing Tatum) from prison. During his time away, she's attempted to correct her ever-worsening depression with a variety of medications, each carrying its own bundle of side effects, from sexual dysfunction to sleepwalking. A psychiatrist (Jude Law) with deep ties to the pharmaceutical industry becomes involved. It's impossible to discuss further specifics without spoiling the movie, but it all adds up to a twisty, chilling, sometimes goofy (in a good way) Hollywood thrill ride. (DAVID SCHMADER)