These things have all already been well-thought through, and in fact numerous "proof of concept" demonstrations
have been conducted. The scienctific principals for extracting resources, particularly the "big three" (air, water & volatiles) is solid, and the technological challenges are not, frankly, terribly difficult.
As for the human factor, these are precisely the sort of studies currently being conducted aboard ISS, where astronauts spend up to 6 months at a time in a microgravity environment far more unforgiving than Mars' comparitively benign .38G. And solutions for overcoming these challenges during the outbound and return phases (centrifugal spin, being just the most obvious example) are also very clearly understood.
Seriously, while this may indeed be quite literally "rocket science", the people who work on this stuff are smart - probably some of the best engineering and medical minds on the planet - the only real obstacles at this point are cost and the desire to do so; everything else is solvable.
Again, I would point you in the direction of Weir's book (a novelization to be sure, but based on real-world principles and techniques), along with the work of Robert Zubrin and Apollo 11 astronaut "Buzz" Aldrin for more detailed examinations of what it would take - and what we can do currently - to launch and successfully return a manned Mars mission.
Going to the moon and back was once thought to be just "science fiction"; so was moving through the air or under water, or even travelling faster than a horse can gallop. People said they couldn't be done, it was simply impossible - until we set our minds to overcoming the obstacles. The only thing we lack to turn "fiction" into reality is the will to do so.