Russian artist Raoef Mamedov's Last Supper features Jesus and his twelve disciples as portrayed by men with Downs syndrome. (Click image for larger version.)

I can never look at an alternative version of the last supper—and there are so many—without recalling the outrage that greeted Folsom's Leather/Fetish Supper a few years back, the only alt version that has ever drawn fire from the religious right. Via MyFormative.