Sounds like the odds are long, but if a change does come, here's how it will go down:
When the Senate returns on Tuesday, it will still technically be in the first legislative day of the session, which means only a simple majority is necessary to change the rules for the rest of the session.
With the support of 51 senators, the rules could be changed to require a “talking filibuster,” forcing those objecting to a bill to stand and explain their reasons, at length. The current practice of routinely requiring a 60-vote majority for a bill through a silent objection would end, breaking the logjam that has made the chamber a well of inefficiency and frustration.
Among the obstacles to this happening: Democratic Senate Majority Leader Harry Reid, who reportedly has been persuaded to "back off the idea." (Need a primer on the case against the filibuster? Right here.)